Description

-            Discover new enabling technologies for organic synthesis based on alternative modes of activation and/or reactivities based on single electron intermediates.

-            Harness their main interest in a green chemistry perspective.

*** Introduction : alternative modes of activation (photochemistry, mechanochemistry, electrochemistry, micro-wave) : why and what for ? Flow chemistry for process intensification and a decreased footprint of chemical synthesis. [VB]

*** Micro-wave technology to reach fast reaction kinetics [VB]

*** Mechanochemistry to lower solvent consumption [VB]

*** Electrosynthesis and electrocatalysis: reagent economy, electrons as traceless redox reagents, metalla-electrocatalysis, new reactivities [MH]

*** Photoredox chemistry : harnessing photons for energy or electron transfer, complementary activation modes (with/without metal catalysts), new set of transformations [NK]

For each technology, a basic fundamental knowledge will be delivered and illustrated by case studies. Benefits arising from coupling with flow set ups will be highlighted. Considerations linked to greenness assessment of the reaction conditions will be the guiding line of this course.

Compétences requises

Advanced organic synthesis

Compétences visées

- Encompass a new way to perform organic transformations through the use of traceless reagents (photo and electro chemistry) and be able to evaluate the inherent benefits and drawbacks from a green chemistry perspective.

- Take up enabling technologies like micro-wave heating, mecanochemistry and/or flow chemistry, when appropriate, to improve reaction conditions.

Contacts

Responsable(s) de l'enseignement

• Valérie Bénéteau
• Maxime Hourtoule
• Nicolas Kern

MCC

Les épreuves indiquées respectent et appliquent le règlement de votre formation, disponible dans l'onglet Documents de la description de la formation.

Régime d'évaluation

CT (Contrôle terminal, mêlé de contrôle continu)

Coefficient

2.25

Évaluation initiale / Session principale - Épreuves

Seconde chance / Session de rattrapage - Épreuves