Description

The objective of the teaching unit is to give a fundamental overview about the supramolecular bond and the host-guest recognition principles. The lecture will detail the thermodynamics behind the formation of supramolecular assemblies, and exemplify the opportunity afforded by the supramolecular toolbox to access new dynamic chemical objects.

The contents are

Definition of Supramolecular Chemistry and historical background

Supramolecular Interactions

The thermodynamics of supramolecular recognition

Cooperativity in host-guest complexes

Chelate effect

Macrocyclic effect

Cryptate effect

Multivalency

Solvation effects in supramolecular recognition

Reversible covalent bonds

From supramolecular chemistry to dynamic combinatorial chemistry

Supramolecular selection and self-replication

Supramolecular chirality

Foldamers and helices

Supramolecular capsules

Templated synthesis (introduction to knots and links)

To complement the course, the Nobel laureates Jean-Marie LEHN and Jean-Pierre SAUVAGE will deliver research seminars dedicated to the course.

Compétences visées

• To appreciate the change of paradigm introduced by supramolecular approaches in chemistry
• To understand, quantify and predict supramolecular phenomena
• To seize the new synthetic opportunities brought by controlling the supramolecular bond

Contacts

Responsable(s) de l'enseignement

• Nicolas Giuseppone