Supramolecular chemistry (introduction)
Master ChimieParcours Chimie des systèmes complexes
Description
The objective of the teaching unit is to give a fundamental overview about the supramolecular bond and the host-guest recognition principles. The lecture will detail the thermodynamics behind the formation of supramolecular assemblies, and exemplify the opportunity afforded by the supramolecular toolbox to access new dynamic chemical objects.
The contents are
Definition of Supramolecular Chemistry and historical background
Supramolecular Interactions
The thermodynamics of supramolecular recognition
Cooperativity in host-guest complexes
Chelate effect
Macrocyclic effect
Cryptate effect
Multivalency
Solvation effects in supramolecular recognition
Reversible covalent bonds
From supramolecular chemistry to dynamic combinatorial chemistry
Supramolecular selection and self-replication
Supramolecular chirality
Foldamers and helices
Supramolecular capsules
Templated synthesis (introduction to knots and links)
To complement the course, the Nobel laureates Jean-Marie LEHN and Jean-Pierre SAUVAGE will deliver research seminars dedicated to the course.
Compétences visées
- To appreciate the change of paradigm introduced by supramolecular approaches in chemistry
- To understand, quantify and predict supramolecular phenomena
- To seize the new synthetic opportunities brought by controlling the supramolecular bond